Apoptosis-induced mitochondrial dysfunction causes cytoplasmic lipid droplet formation
نویسندگان
چکیده
منابع مشابه
Mitochondrial dysfunction in lyssavirus-induced apoptosis.
Lyssaviruses are highly neurotropic viruses associated with neuronal apoptosis. Previous observations have indicated that the matrix proteins (M) of some lyssaviruses induce strong neuronal apoptosis. However, the molecular mechanism(s) involved in this phenomenon is still unknown. We show that for Mokola virus (MOK), a lyssavirus of low pathogenicity, the M (M-MOK) targets mitochondria, disrup...
متن کاملPhospholipase A2 regulation of lipid droplet formation.
The classical regard of lipid droplets as mere static energy-storage organelles has evolved dramatically. Nowadays these organelles are known to participate in key processes of cell homeostasis, and their abnormal regulation is linked to several disorders including metabolic diseases (diabetes, obesity, atherosclerosis or hepatic steatosis), inflammatory responses in leukocytes, cancer developm...
متن کاملMitochondrial dysfunction in resveratrol-induced apoptosis in QGY-7701 cells.
This study aims to evaluate the cytotoxicity of resveratrol on QGY-7701 cells via a cell viability assay, and determine the cytological alterations and damages that result. Resveratrol was found to inhibit QGY-7701 cell growth and decrease their viability in a remarkably dose-dependent manner. Resveratrol exposure also induced an increase in Caspase-3 activity and a decrease in Bcl-2, which cau...
متن کاملIsolongifolene attenuates rotenone-induced mitochondrial dysfunction, oxidative stress and apoptosis.
The present study was carried out to investigate the neuroprotective effects of isolongifolene (ILF), a tricyclic sesquiterpene of Murraya koenigii, against rotenone-induced mitochondrial dysfunction, oxidative stress and apoptosis in a cellular model. SH-SY5Y human neuroblastoma cells were divided into four experimental groups (control, rotenone (100 nM), ILF (10 microM) + rotenone (100 nanoM)...
متن کاملAutophagy Regulates Lipid Droplet Formation and Adipogenesis
Proteolysis in eukaryotic cells can be separated into two major pathways: one is mediated by the ubiquitin-proteasome system and by the autophagy-lysosome system. Substrates of lysosomes may be taken through heterophagocytosis, endocytosis, or autophagy into heterophagosomes, early endosomes, or autophagosomes, which receive lysosomal enzymes via transporting vesicles from the trans-Golgi netwo...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Cell Death & Differentiation
سال: 2012
ISSN: 1350-9047,1476-5403
DOI: 10.1038/cdd.2012.34